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The tragedy of having pets is knowing that one day you’ll have to say goodbye to your loved ones. The average dog lives between 10 and 13 years, depending on its breed, but researchers believe that with the help of a drug called rapamycin, their lives can be extended by around three years.

Rapamycin was discovered nearly 50 years ago from soil that was found on Easter Island, an island in the South Pacific famous for its mysterious Moai statues. The drug was approved by the FDA for human use because it suppresses the immune system to prevent it from attacking donated organs.

“Rapamycin seems to have the ability to ‘reset’ immune function by reducing the increase in chronic inflammation that goes along with aging,” Dr. Matt Kaeberlein of the Dog Aging Project says according to Yahoo. “This also seems to have benefits beyond the immune system in all sorts of tissues and organs.”

Early tests on dogs, rats and mice show the drug is very effective at reducing the aging process. It was found to reduce age-related declines in mice, most notably in the heart, ovaries, brain and oral cavity. It was also found to boost the immune system’s response to cancers and COVID-19.

The study found that rapamycin increased the mice’s average life spans by up to 25%. If the same results are found in dogs, then a canine with a 12-year life span could presumably live to 15.

“You can take an old heart or an old immune system, treat a mouse with rapamycin for eight weeks, and see that function improve. I know it sounds a little bit like science fiction, but when you actually look at the data, it’s quite remarkable,” Kaeberlein says, according to KRTV.

The drug is found to have serious side effects in humans including cancer, diabetes and infections. However, Kaeberlein believes that they are partially the result of the drug being administered to people who already have health problems. Further, the drug will be administered in much smaller doses to dogs, compared to humans who have had organ transplants.

The University of Washington’s Dog Aging Project is taking this research a step further by doing a nationwide study on almost 600 dogs.

The Dog Aging Project is recruiting dogs to participate in the largest #canine health study ever conducted. This is an opportunity to be part of a research project that can dramatically extend what we know about #health and #aging in our dogs.https://vimeo.com/dogagingproject/joinu00a0u2026

— Dog Aging Project (@Dog Aging Project)
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Kaeberlein believes that a dog is just as likely as a mouse to benefit from the effects of rapamycin, although the reaction will differ by breed. He believes that when it becomes widely used by veterinarians it’ll be administered to larger dogs at around 6 or 7 years and smaller dogs at 9 or 10.

The drug is already approved for use in humans by the FDA, so further studies will help dog owners and veterinarians decide whether it’s a safe treatment. “If our trial shows compelling evidence for beneficial effects and little in the way of side effects, I suspect many veterinarians will become more comfortable prescribing it for owners who request it,” Kaeberlein says.

There is never a right time to say goodbye to our beloved pets. But if these studies turn out as researchers predict, we may be able to have a few more years of memories with our dogs before they cross the Rainbow Bridge.

The 2022 WNBA Draft is less than a week away, as the three-round event will begin at 7 p.m. ET on Monday, April 11 on ESPN, with some debate still ongoing about who will end up as the top overall pick.

Baylor forward NaLyssa Smith and Kentucky guard Rhyne Howard are the consensus top two players in this year’s draft, but what order they’ll go in remains a mystery. Adding another layer to that debate was news breaking that the Atlanta Dream had acquired the No. 1 overall pick from the Washington Mystics, moving up from the third position by sending Washington this year’s second rounder at No. 14 overall and the right to swap 2023 first rounders with the first round pick Atlanta received from Los Angeles in a trade earlier this offseason.

Washington moves back and seems likely to end up with Ole Miss center Shakira Austin, while the Dream will get their choice at the top of the draft. Atlanta is a team in rebuilding mode after a 2021 season that saw coach Nicki Collen leave for the Baylor job just before the season started and then had internal turmoil involving a fight that went viral between Courtney Williams and Crystal Bradford, as well as suspending their 2020 first round pick Chennedy Carter for conduct detrimental to the team in the middle of the season.

All three of those players are gone from this year’s roster, and as such the Dream will go with who they think is the best player available at the top of the draft to pair with last year’s third overall selection, guard Aari McDonald, and clearly have one of Smith or Howard in mind. We’ll have to wait until Monday night to find out which they’re selecting and which will stay on the board for the Indiana Fever picking second.

Following the tragic passing of iconic Jeopardy! host Alex Trebek, The Big Bang Theory star Mayim Bialik emerged as a fan favorite, and reportedly, was almost offered the top spot before executive producer Mike Richards essentially took it for himself, causing a fiasco for the beloved game show. However, since then, Bialik has been hosting Jeopardy! specials and occasionally filling in for Ken Jennings as the show takes its time picking Trebek’s successor once and for all. (Despite initially not wanting to be the permanent host because of her busy schedule, Bialik is reportedly still in the mix for the full-time gig.)

In a lengthy interview with The Daily Beast to promote her directorial debut, As They Made Us, starring Dustin Hoffman and Candice Bergen, Bialik revealed what it was like to experience the chaotic hosting mess and how the Jeopardy! producers have been helping her fill Trebek’s shoes behind the podium (by calming down a little), which is no easy task:

The role of Jeopardy! host carries a lot of authority. You’re viewed as a bastion of truth. Does that burden weigh on you?

I think as a woman there’s a special consideration, because when women sound definitive or stern it’s a different message than when men sound definitive or stern. And a lot of times when people will say, “Oh, you sound like you think you know it all,” I’ll think, gosh, that’s just because I’m using an affirmative voice. One of the neat things about having a woman in this role is it’s bringing up a lot of questions about the labels we put on those things. One of my biggest challenges is I’m so impressed that people know the answers that they’ve asked me to tone down how excited I am when people get them right, which I think is s a great note to get.

Claire McNear, who wrote a book on Jeopardy! and the article about Mike Richards that got eventually got him booted, called the above excerpt to attention.

Bialik also touched on the controversy regarding her prior vaccine skepticism — this was a full decade before COVID, by the way, and she got the jab — which was a topic that eventually engulfed Aaron Rodgers, who was also one of the top Jeopardy! guest hosts. Mayim may have been partially referencing those issues in the below excerpt.

“We have the complete ability to have access to people, and as I’ve experienced, you can have people pass around a piece of information that’s not true on Twitter and it can grow exponentially,” Bialik said. “I think Jeopardy! was a perfect example of all the things that can go wrong in terms of social media and the handling by social media of certain information that normally people would know very little about.”

(Via The Daily Beast)

There’s nothing that can cure the rough mid-week blues like a little vicarious living. The characters in your average feel-good Netflix flick are great, but the smiles of real people are the best way to lift your spirits.

Enter, Sundream Tulum. The destination music festival, created in collaboration with Rüfüs Du Sol and Tulum’s premiere hotel Papaya Playa Project, hosted its debut event across two weekends in March (March 3-6 and March 10-13). Nestled in the coastal jungle, Sundream Tulum offered the ultimate hybrid of a weekend-long festival rager and a well-deserved peaceful vacation.

Both weekends featured a slew of top-notch musical performances followed by a Sunday full of recovery and wellness activities. The lineup included Rüfüs Du Sol, Bob Moses, Lee Burridge, WhoMadeWho, Jan Blomqvist, Cassian, Magdalena, Eelke Kleijn, Mira, Sainte Vie, Amémé, Bora Uzer, Sarah Kreis, Paraleven, Etna Calvi, Dramian, and Jimeno.

If you’re in need of a pick-me-up, check out the photos of Sundream Tulum below. The beachside views, out-there ensembles, and all-around good vibes are sure to turn your day around.

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Of all the rap artists currently preparing to release new projects, the ones hip-hop fans might most be surprised to see collaborate would almost certainly be Coi Leray and Pusha T. They couldn’t be any more different if they tried; Coi Leray’s art for the upcoming Trendsetter is as bright and colorful as songs like “Blick Blick,” while Pusha T is pushing his forthcoming album It’s Almost Dry with dark, gritty fare such as “Diet Coke” and “Neck And Wrist.”

But after her appearance on New York City’s The Breakfast Club to promote Trendsetter, Coi says she’s planning to hunt down and work with the more serious-minded elder rapper after being told by the show’s hosts that her music isn’t for them. After Charlamagne the God told her, “I’m 43, I don’t think your music’s for me,” Coi called the hosts “dinosaurs” and joked that while she doesn’t listen to Pusha T herself, she’s more than willing to try to blend their audiences with a collaboration.

“Pusha-T, don’t hate me because I love you, but he’s stuck on you, Pusha-T,” she said. “And now I’m about to come collab with you, and we’re gonna go crazy.”

Watch Coi Leray’s full interview with The Breakfast Club above.

The Simpsons has been on for 33 seasons. Think about that for a second. The first episode, “Simpsons Roasting on an Open Fire,” premiered less than a month after Back to the Future Part II hit theaters. The longest-running scripted series in American TV history isn’t going away anytime soon, either: the cast has already started recording season 34, and Yeardley Smith, the voice of Lisa, thinks it will continue past that.

“We had a pickup for 33 and 34, but I feel like we would be given a pretty big heads-up for the last season because, at the very least, Disney who bought Fox, all but Fox News and Fox Sports, part of the reason they bought it was for The Simpsons,” Smith told The Movie Dweeb YouTube channel (“dweeb” was an insult when The Simpsons premiered in 1989; now it’s a badge of honor). “Also, if it was the last season, I think they would want to capitalize on that and make bazillions on advertising.” She isn’t worried about losing the job she’s had for over three decades “considering how much content streaming services need… If somebody is literally going to binge your whole series in a weekend, you’re f*cked! How do you keep that voracious appetite fed? It’s a huge thing.”

Smith also discussed the long-rumored sequel to 2007’s The Simpsons Movie, which she thinks will happen… eventually. And when it does (hopefully not at the same time as the writers and animators are also working on the show, for their sanity), she has an idea in mind. “I do really believe that there will be a number two, and my pitch is that it should be a Christmas movie, so that it has annual relevance for the rest of time,” she said.

Smith’s concept is similar to showrunner Al Jean’s idea for the series finale. “I mentioned that there would be an ending where the last episode, they’d be going back to the Christmas pageant from the first episode, so that the whole series was a continuous loop,” he said. “That’s how I would end it, if I had to.”

They should combine the two ideas, so look forward to that in 2047.

(Via ScreenRant)

Twitter is a daily graveyard of takes nobody asked for. A few go viral and live in the public consciousness for a few hours, others are self-consciously deleted by their authors for underperforming. But every once in a while, someone will pose a question broad enough to resonate with the Tweeting public at large and inspire some takes that are actually worth reading.

Like Twitter user Michael Realman (@trichesfaucons) who tweeted “We’re canceling each other over food takes today. Post your cancellable food take.”

The tweet, which was posted yesterday morning, has since garnered over 2k retweets, 81k quote tweets, and 47k likes. By now most of the takes worth reading are in, and it seems like a lot of people weighed in, including our own Vince Mancini.

Sure, we’re totally biased here but you know what? This isn’t such a bad take. Sure, I absolutely hated El Pollo Loco’s awful attempt at quesabirria but we’ve given El Pollo Loco the top spot in our fast food tacos ranking, so this one gets a strong cosign from me!

Check out some of the best Twitter takes below. Some are good enough to stand on their own while others are downright ridiculous. A lot of these tweets we will let stand on their own, whether we agree or disagree, but on some occasions, the take was so jaw-dropping that we couldn’t hold our tongue and had to respond.

It’s a take of a take! We’re truly living in some sort of social media hell.

Brussel Sprouts are objectively great, did Nunes tweet this himself? It wouldn’t be the weirdest thing he’s done on Twitter.

They certainly don’t make everything butter, but anything? Truffle oil on pasta? Come on!

Are we allowed to show this on the internet? What am I looking at here?

Robbie we applaud you for this very brave (very wrong) stance.

Great coffee can be surprisingly nuanced and naturally sweet, so we can’t agree with this take.

Hard co-sign.

Edible, sure, ‘fucking amazing?’ Not a chance.

We’ll try it but we can’t imagine candy corn adding anything but a gelatinous texture that gets stuck in your teeth.

Hmm.

Probably the craziest take so far.

Respect.

An avocado presumably hurt this person.

Just wow.

If ever there was an unexpected supergroup, it would be the unnamed team-up of mashup DJ Girl Talk with blog rap icons Big KRIT, Smoke DZA, and Wiz Khalifa. The group popped up from out of nowhere with their debut single “Put You On” in March, then continued their rollout with “How The Story Goes” a few weeks later. Today, they shared another party-ready anthem, “Ain’t No Fun,” along with a music video that captures the hedonistic spirit of the song.

Girl Talk explained the production philosophy behind “Ain’t No Fun” in a statement, calling it “a flip on the concept of Snoop’s original, kind of from the female perspective of the titular line. I wanted to keep the production diverse throughout the project, while still maintaining a cohesive feel. This beat stands out in the context of the album because it doesn’t have a sample and uses a more minimal style. But I thought that with some of the specific sound design and the overall energy, it really connected to the project as a whole.”

The project in question is Full Court Press, which is due on April 8 via Asylum.

Watch Wiz Khalifa, Big KRIT, Smoke DZA, and Girl Talk’s “Ain’t No Fun” video above.

Artists covered here are Warner Music artists. Uproxx is an independent subsidiary of Warner Music Group.

The last few years have been a bummer to say the least, but Austin-based four-piece Good Looks are attempting to flip the script on their debut album Bummer Year. Much of the LP is inspired by the sounds of vocalist Tyler Jordan’s youth. Growing up in a South Texas coastal town, he first learned to sing in his father’s church. Eventually, he became inspired by artists whose music carried an important message — something he infuses into the songs on Bummer Year. As self-described “blue-collar bad boys being blatantly vulnerable,” tracks like “Vision Boards” grapple with self-doubt and perceived shortcomings over washed-out guitars and endlessly dreamy melodies.

Emphasized by ripping chords, warm-toned melodies, and slight country twang, Bummer Year is an album about learning how to take care of yourself and prioritize the relationships around you. After all, it’s not possible to get through a bummer year without a good support system. Ahead of the release of the debut LP, out this Friday on Keeled Scales, Good Looks sat down with Uproxx to talk about their musical inspirations, impressive beer shotgunning talents, and love of Willie Nelson on the latest Indie Mixtape 20 Q&A.

What are four words you would use to describe your music?

Honest, Literal, Songwriter, Rocknroll, I cheated on the last word

It’s 2050 and the world hasn’t ended and people are still listening to your music. How would you like it to be remembered?

I’m not sure, I guess it doesn’t really matter that much to me. Growing up, music was there for me in my darkest moments. It was always an escape. I guess I hope that my music could help someone else through a similar experience.

What’s your favorite city in the world to perform?

It’s probably a tie between Little Rock and Reno. They’re both small cities with super supportive music scenes.

Who’s the person who has most inspired your work, and why?

Well, corporations aren’t people and neither are nonprofit folk fests, but if they were, the Kerrville Folk Festival has been the single most important thing in terms of inspiration. I would not be the writer that I am without that place. I’ve been attending religiously since 2009.

Where did you eat the best meal of your life?

This is a hard question to answer, but probably at Habanero Cafe on Oltorf.

What album do you know every word to?

There are probably a few, but the one that comes to mind is Willie Nelson’s Phases And Stages.

What was the best concert you’ve ever attended?

Cate Le Bon inside at the Mohawk on the Mug Museum tour

What is the best outfit for performing and why?

I don’t know man, I wear a lot of T-shirts. I’ve been recently leaning into wearing boots more on stage. They just make you feel tough and add a little bit of swagger.

Who’s your favorite person to follow on Twitter and/or Instagram?

Patti Smith’s Instagram account is a God damn gift to humanity

What’s your most frequently played song in the van on tour?

Unfortunately, I think it’s Darude’s Sandstorm. haha

What’s the last thing you Googled?

Whether the “l” is lowercase or uppercase in Cate Le Bon’s name.

What album makes for the perfect gift?

Anything that The Numero Group puts out. All of their album packages are so nice and thought out.

Where’s the weirdest place you’ve ever crashed while on tour?

Walker Lake state park in the middle of nowhere Nevada.

What’s the story behind your first or favorite tattoo?

Actually nobody in our band has a single tattoo, which is bizarre really.

What artists keep you from flipping the channel on the radio?

Anything with Gerry Rafferty or George Jones.

What’s the nicest thing anyone has ever done for you?

Wow, this is a really hard question to answer. My life has been filled with the kindness of strangers and friends.

What’s one piece of advice you’d go back in time to give to your 18-year-old self?

To be more willing to say yes and let people in. I spent a long time shutting people out, and the key to success in the music business is all about connection and who you know. I wish I had realized that sooner.

What’s the last show you went to?

I think it might have been Buck Meek at 3ten.

What movie can you not resist watching when it’s on TV?

Almost Famous

What’s one of your hidden talents?

I’m a world-class shotgunner of beer.

Bummer Year is out 4/8 via Keeled Scales. Pre-order it here.

As music fans know by now, longtime Foo Fighters drummer Taylor Hawkins died last month. After somebody passes away, their work usually receives some renewed attention. Now Billboard reveals this has indeed happened with Foo Fighters on the latest Billboard charts.

The band’s Greatest Hits compilation rose from No. 8 to the very top of the Top Hard Rock Albums chart, its first time at No. 1 since it debuted there in November 2009. It also rose from No. 24 to No. 2 on the Top Rock Albums chart (a new peak) and up from No. 147 all the way to No. 18 on the Billboard 200 chart.

“Everlong,” one of the band’s signature songs, also re-entered the Hot Hard Rock Songs chart at No. 1, topping the chart (which launched in 2020) for the first time. It’s worth noting Hawkins doesn’t actually drum on the album version of the song since he joined the band after it was recorded, although he does appear in the track’s video.

Those chart are all dated April 9 and reflect the tracking week from March 25 to 31, meaning the represent the days following Hawkins’ March 25 death.

This comes shortly after Hawkins won some posthumous Grammys with Foo Fighters, as the band picked up the awards for Best Rock Album, Best Rock Song, and Best Rock Performance last weekend.